Motif ID: FOX{C1,C2}.p2

Z-value: 0.485


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC1chr6_+_1610680-0.251.8e-01Click!
FOXC2chr16_+_86600856-0.154.4e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_63450486 0.682 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr8_-_27115935 0.593 STMN4
stathmin-like 4
chr21_-_43735462 0.580 TFF3
trefoil factor 3 (intestinal)
chr3_+_133495925 0.548 TF
transferrin
chr10_+_7745341 0.544 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745354 0.542 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_13276327 0.519 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr10_+_7745325 0.507 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_+_140165875 0.474 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr7_-_99573637 0.471 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr21_+_43823970 0.447 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chr2_-_119605758 0.440 NM_001426
EN1
engrailed homeobox 1
chr12_-_25706177 0.438 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr12_+_69742130 0.431 NM_000239
LYZ
lysozyme
chr10_+_96522457 0.429 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr20_-_44175995 0.422 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr10_+_7745229 0.413 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_71494460 0.407 NM_031889
ENAM
enamelin
chr20_+_9198036 0.403 NM_182797
PLCB4
phospholipase C, beta 4
chr12_+_69742140 0.396 LYZ
lysozyme
chr5_+_156820161 0.394 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr21_+_31768294 0.385 NM_181599
KRTAP13-1
keratin associated protein 13-1
chrX_+_15525430 0.372 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr4_+_186350543 0.365 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr9_-_34397786 0.363 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr4_+_120056938 0.361 NM_016599
MYOZ2
myozenin 2
chr12_+_15125955 0.352 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr5_+_173472692 0.350 NM_015980
HMP19
HMP19 protein
chrX_+_41548225 0.349 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr10_+_7745284 0.338 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_+_140213968 0.331 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr5_-_35230548 0.323 PRLR
prolactin receptor
chr1_+_244515936 0.317 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr8_-_110620220 0.315 SYBU
syntabulin (syntaxin-interacting)
chr22_+_31003069 0.308 NM_000355
NM_001184726
TCN2

transcobalamin II

chr11_+_118175294 0.296 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr15_-_58306185 0.295 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr13_-_53313924 0.285 NM_001011705
NM_007015
LECT1

leukocyte cell derived chemotaxin 1

chr6_+_47624222 0.257 NM_153839
GPR111
G protein-coupled receptor 111
chr1_-_150738255 0.254 CTSS
cathepsin S
chr13_-_26625164 0.251 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr16_+_78062985 0.239 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr21_-_43735705 0.236 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr2_+_127413739 0.236 GYPC
glycophorin C (Gerbich blood group)
chr8_-_27115897 0.225 NM_030795
STMN4
stathmin-like 4
chr16_+_82068958 0.224 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_158300517 0.223 NM_004288
CYTIP
cytohesin 1 interacting protein
chr14_+_88471467 0.209 NM_003608
GPR65
G protein-coupled receptor 65
chr11_+_111385509 0.207 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr6_+_12717036 0.202 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr7_-_92848837 0.198 NM_198151
HEPACAM2
HEPACAM family member 2
chr4_+_71263598 0.197 NM_021225
PROL1
proline rich, lacrimal 1
chr11_+_6226797 0.196 NM_173525
C11orf42
chromosome 11 open reading frame 42
chr1_+_104159953 0.188 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr17_+_48821106 0.187 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr10_-_17171789 0.186 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr5_+_35856990 0.184 NM_002185
IL7R
interleukin 7 receptor
chr17_-_41836132 0.184 NM_025237
SOST
sclerostin
chrX_-_130423199 0.178 IGSF1
immunoglobulin superfamily, member 1
chr12_-_56236614 0.177 NM_002429
MMP19
matrix metallopeptidase 19
chr3_-_114343791 0.176 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr19_+_15052298 0.176 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr11_-_59633942 0.171 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr16_+_57050985 0.166 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr6_+_131958441 0.160 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr16_-_72206023 0.158 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr20_-_44168128 0.156 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr10_+_96698409 0.156 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr8_+_103563847 0.154 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr21_-_43816123 0.152 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr7_-_50633042 0.152 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr20_+_9494995 0.147 NM_001199897
NM_012261
LAMP5

lysosomal-associated membrane protein family, member 5

chr17_-_10741398 0.147 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr17_+_3118911 0.146 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr12_-_24103953 0.142 SOX5
SRY (sex determining region Y)-box 5
chr1_-_206945725 0.141 NM_000572
IL10
interleukin 10
chr3_-_100712248 0.140 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_+_26485510 0.139 NM_024869
FAM110D
family with sequence similarity 110, member D
chr7_-_50628744 0.137 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr1_-_157670280 0.136 NM_052939
FCRL3
Fc receptor-like 3
chr5_+_140180782 0.135 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr17_+_8214139 0.135 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr15_+_34261088 0.134 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr6_+_17282931 0.129 NM_153020
RBM24
RNA binding motif protein 24
chr18_-_40695483 0.128 NM_002930
RIT2
Ras-like without CAAX 2
chr1_-_24239758 0.127 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr3_+_149192479 0.127 TM4SF4
transmembrane 4 L six family member 4
chr3_-_119278402 0.126 NM_005191
CD80
CD80 molecule
chr3_+_113616317 0.124 NM_001172105
GRAMD1C
GRAM domain containing 1C
chrX_+_125953746 0.123 NM_001122716
CXorf64
chromosome X open reading frame 64
chr6_-_29343063 0.122 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr5_-_35230822 0.121 NM_000949
PRLR
prolactin receptor
chr8_+_105352050 0.120 NM_030788
TM7SF4
transmembrane 7 superfamily member 4
chr12_+_54378929 0.120 NM_017409
HOXC10
homeobox C10
chr6_+_72926144 0.119 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr8_+_55528626 0.118 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr1_+_84768333 0.117 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr1_-_217250230 0.117 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr2_+_150187028 0.114 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr19_+_15852200 0.113 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr19_-_14992166 0.113 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr3_-_93692592 0.112 PROS1
protein S (alpha)
chr3_+_108541544 0.111 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr2_+_69201704 0.111 NM_019617
GKN1
gastrokine 1
chr1_+_120049825 0.110 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr4_-_84035888 0.109 PLAC8
placenta-specific 8
chr11_-_61124223 0.108 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr11_+_111789658 0.107 C11orf52
chromosome 11 open reading frame 52
chr3_+_149192367 0.107 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr6_-_152702329 0.107 SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_-_135819953 0.107 TSC1
tuberous sclerosis 1
chr16_-_53737713 0.106 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr1_-_151148425 0.105 NM_013353
TMOD4
tropomodulin 4 (muscle)
chr15_-_90349819 0.104 ANPEP
alanyl (membrane) aminopeptidase
chrX_+_37639306 0.101 CYBB
cytochrome b-245, beta polypeptide
chr14_-_94854910 0.101 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_202129731 0.101 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr11_+_15136483 0.101 NM_001042536
INSC
inscuteable homolog (Drosophila)
chr14_-_94855120 0.100 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr2_+_102927961 0.100 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr20_-_33460558 0.100 NM_178026
GGT7
gamma-glutamyltransferase 7
chr22_+_51176623 0.099 NM_001097
ACR
acrosin
chr20_+_2276612 0.098 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr2_+_191002485 0.098 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr5_+_38445577 0.098 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr1_-_26644755 0.098 NM_145345
UBXN11
UBX domain protein 11
chr2_-_49381555 0.097 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr11_+_111789600 0.097 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr8_-_86290333 0.097 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr4_-_84035908 0.096 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr13_+_52436116 0.096 NM_031290
CCDC70
coiled-coil domain containing 70
chr19_+_55476651 0.092 NM_001174081
NLRP2
NLR family, pyrin domain containing 2
chr7_+_28475233 0.091 NM_004904
CREB5
cAMP responsive element binding protein 5
chr7_+_148036528 0.091 CNTNAP2
contactin associated protein-like 2
chr3_-_15642969 0.090 HACL1
2-hydroxyacyl-CoA lyase 1
chr1_+_244214576 0.090 ZNF238
zinc finger protein 238
chr6_+_7108184 0.089 RREB1
ras responsive element binding protein 1
chr15_+_76352270 0.089 NM_152335
C15orf27
chromosome 15 open reading frame 27
chr6_-_52710892 0.089 NM_153699
GSTA5
glutathione S-transferase alpha 5
chr2_-_190927321 0.088 NM_005259
MSTN
myostatin
chr18_-_56296188 0.087 NM_052947
ALPK2
alpha-kinase 2
chr5_+_72469022 0.087 NM_153217
TMEM174
transmembrane protein 174
chr14_+_29236882 0.085 FOXG1
forkhead box G1
chr4_+_160188997 0.085 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr9_-_104198045 0.085 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr12_+_52306112 0.083 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr11_-_9225780 0.082 DENND5A
DENN/MADD domain containing 5A
chr16_+_82068830 0.082 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr12_+_100867550 0.081 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr1_-_217113007 0.081 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chrM_+_9725 0.081


chr11_+_59824054 0.081 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr5_-_156593178 0.080 NM_130899
FAM71B
family with sequence similarity 71, member B
chr10_-_112678902 0.079 NM_001195304
NM_001195305
NM_001195307
NM_001243783
BBIP1



BBSome interacting protein 1



chr4_+_25657434 0.079 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr3_+_185046682 0.078 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr5_+_140474198 0.078 NM_018936
PCDHB2
protocadherin beta 2
chr9_+_124048396 0.078 GSN
gelsolin
chr6_+_30908776 0.077 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chrX_+_68835910 0.077 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr4_-_122854192 0.077 NM_003305
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr6_-_29055048 0.077 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr7_-_55930444 0.076 NM_207366
SEPT14
septin 14
chr3_-_15643063 0.075 NM_012260
HACL1
2-hydroxyacyl-CoA lyase 1
chr6_-_155777036 0.074 NM_015718
NOX3
NADPH oxidase 3
chr5_-_39424930 0.074 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr5_+_173472737 0.074 HMP19
HMP19 protein
chr14_+_76071804 0.074 NM_001195283
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr1_-_36948423 0.073 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr17_-_3794036 0.073 NM_172206
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr17_-_3599298 0.072 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr17_-_36105005 0.070 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr4_-_100140330 0.070 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chrX_+_74493893 0.070 NM_145052
UPRT
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr11_+_62009723 0.069 NM_006551
SCGB1D2
secretoglobin, family 1D, member 2
chr17_-_53800074 0.069 NM_018286
TMEM100
transmembrane protein 100
chrX_+_37639246 0.069 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr5_+_176873795 0.068 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr6_+_123100860 0.068 FABP7
fatty acid binding protein 7, brain
chr7_-_87856282 0.067 NM_198901
SRI
sorcin
chr10_-_104178569 0.067 PSD
pleckstrin and Sec7 domain containing
chr1_+_163038934 0.066 NM_001113381
RGS4
regulator of G-protein signaling 4
chr14_-_24777064 0.066


chr3_-_116164363 0.065 NM_002338
LSAMP
limbic system-associated membrane protein
chr6_+_28109611 0.064 NM_006298
ZNF192
zinc finger protein 192
chr6_+_22569656 0.064 NM_138574
HDGFL1
hepatoma derived growth factor-like 1
chr2_+_179184970 0.064 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr4_+_36283243 0.064 NM_001136536
DTHD1
death domain containing 1
chr17_-_79623561 0.064 NM_002602
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr2_+_33701678 0.063 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr11_-_5255712 0.062 NM_000519
HBD
hemoglobin, delta
chr3_-_42917191 0.062 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr1_+_27719151 0.062 NM_005281
GPR3
G protein-coupled receptor 3
chr16_+_69958900 0.062 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr15_-_42186274 0.061 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr20_+_20037289 0.061 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr5_+_140201221 0.060 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr17_-_47439326 0.060 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr11_+_65271145 0.060


chr1_-_203155910 0.060 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 1.86e-05 GO:0071944 cell periphery
1.48 1.44e-04 GO:0005886 plasma membrane
1.74 2.23e-04 GO:0005576 extracellular region
1.69 3.98e-04 GO:0044459 plasma membrane part
1.89 1.97e-03 GO:0005887 integral to plasma membrane
2.74 3.19e-03 GO:0031012 extracellular matrix
1.86 3.29e-03 GO:0031226 intrinsic to plasma membrane
2.81 8.04e-03 GO:0005578 proteinaceous extracellular matrix
25.78 2.68e-02 GO:0030868 smooth endoplasmic reticulum membrane
1.82 3.71e-02 GO:0044421 extracellular region part
1.25 4.64e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.60 1.12e-03 GO:0003823 antigen binding
1.75 2.88e-03 GO:0004872 receptor activity
1.63 7.01e-03 GO:0004871 signal transducer activity
1.63 7.01e-03 GO:0060089 molecular transducer activity
3.94 1.97e-02 GO:0046906 tetrapyrrole binding
1.74 4.54e-02 GO:0004888 transmembrane receptor activity